In Psoriasis Lesional Skin the Type I Interferon Signaling Pathway Is Activated, Whereas Interferon-α Sensitivity Is Unaltered
نویسندگان
چکیده
منابع مشابه
Suppression of type I interferon signaling proteins is an early event in squamous skin carcinogenesis.
PURPOSE IFN-based therapy has been shown to be active in the treatmentof squamous cell carcinoma (SCC) of the skin, the most aggressive form of non-melanoma skin cancer. Based largely on this activity, we began programmatically examining the expression of IFN-stimulated gene factor 3 (ISGF-3) proteins (signal transducers and activators of transcription 1alpha/beta, signal transducers and activa...
متن کاملActivation of the Type I Interferon Pathway Is Enhanced in Response to Human Neuronal Differentiation
Despite the crucial role of innate immunity in preventing or controlling pathogen-induced damage in most, if not all, cell types, very little is known about the activity of this essential defense system in central nervous system neurons, especially in humans. In this report we use both an established neuronal cell line model and an embryonic stem cell-based system to examine human neuronal inna...
متن کاملType I Interferon Response Is Delayed in Human Astrovirus Infections
Type I interferon (IFN) activation and its subsequent effects are important in the response to viral infections. Here we show that human astroviruses (HAstVs), which are important agents of acute gastroenteritis in children, induce a mild and delayed IFN response upon infecting CaCo-2 cells. Although IFN-β mRNA is detected within infected cells and supernatant from infected cells show antiviral...
متن کاملMDA5 is SUMOylated by PIAS2β in the upregulation of type I interferon signaling.
Retinoic acid-inducible protein I (RIG-I) and melanoma differentiation-associated gene 5 (MDA5) are cytosolic viral RNA sensors that induce type I interferon production (IFN). In this study, we found that MDA5 undergoes inducible SUMOylation by small ubiquitin-like modifier-1 (SUMO-1) in response to polyI:C stimulation. Enhanced SUMOylation of MDA5 by exogenously expressed SUMO-conjugating enzy...
متن کاملAdvances in Brief Suppression of Type I Interferon Signaling Proteins Is an Early Event in Squamous Skin Carcinogenesis
Purpose: IFN-based therapy has been shown to be active in the treatment of squamous cell carcinoma (SCC) of the skin, the most aggressive form of non-melanoma skin cancer. Based largely on this activity, we began programmatically examining the expression of IFN-stimulated gene factor 3 (ISGF-3) proteins (signal transducers and activators of transcription 1 / , signal transducers and activators ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Investigative Dermatology
سال: 2004
ISSN: 0022-202X
DOI: 10.1046/j.0022-202x.2003.22113.x